Scott established her fashion career by working as a stylist with photographers like Helmut Newton, Karl Lagerfeld and Mario Sorrenti. She worked as a costume designer for movies like Eyes Wide Shut and Ocean's Thirteen. After she launched her first fashion collection in 2006, her line quickly became a favorite among celebrities including Sarah Jessica Parker, Angelina Jolie and Nicole Kidman. Michelle Obama and Carla Bruni-Sarkozy have also worn her clothing.
This February, Scott canceled her scheduled London Fashion Week runway show.
Scott has been linked romantically to Mick Jagger since 2001.